Assay Detail
Functional
CHEMBL954849
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum GCO3 after 72 hrs by SYBR green assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.64 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144037 | — | — | 1 | 8.15 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.00 |
| CHEMBL448846 | — | — | 1 | 7.92 |
| CHEMBL317364 | — | — | 1 | 7.89 |
| CHEMBL147802 | — | — | 1 | 7.80 |
| CHEMBL485881 | — | — | 1 | 7.70 |
| CHEMBL519708 | — | — | 1 | 7.58 |
| CHEMBL519493 | — | — | 1 | 7.35 |
| CHEMBL356292 | — | — | 1 | 7.31 |
| CHEMBL486502 | — | — | 1 | 7.28 |
| CHEMBL486501 | — | — | 1 | 7.21 |
| CHEMBL146333 | — | — | 1 | 7.18 |
| CHEMBL484296 | — | — | 1 | 7.13 |
| CHEMBL519636 | — | — | 1 | 5.83 |
| CHEMBL488146 | — | — | 1 | 5.79 |
| CHEMBL482469 | — | — | 1 | 5.78 |
| CHEMBL528101 | — | — | 1 | 5.65 |
| CHEMBL482470 | — | — | 1 | 5.64 |
| CHEMBL443725 | — | — | 1 | 5.63 |
| CHEMBL488145 | — | — | 1 | 5.46 |
| CHEMBL488359 | — | — | 1 | 5.35 |
| CHEMBL216926 | — | — | 1 | 5.28 |
| CHEMBL341638 | — | — | 1 | 5.25 |
| CHEMBL502643 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144037 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL448846 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL317364 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL147802 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL485881 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL519708 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL519493 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL356292 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL486502 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL486501 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL146333 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL484296 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL519636 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL488146 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL482469 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL528101 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL482470 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL443725 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL488145 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL488359 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL216926 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL341638 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL502643 | — | IC50 | = | 5740.0 | nM | 5.24 |