Assay Detail
Functional
CHEMBL954850
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.21 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144037 | — | — | 1 | 7.54 |
| CHEMBL317364 | — | — | 1 | 7.52 |
| CHEMBL485881 | — | — | 1 | 7.07 |
| CHEMBL448846 | — | — | 1 | 7.05 |
| CHEMBL147802 | — | — | 1 | 6.99 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.80 |
| CHEMBL356292 | — | — | 1 | 6.74 |
| CHEMBL484296 | — | — | 1 | 6.45 |
| CHEMBL146333 | — | — | 1 | 6.29 |
| CHEMBL519493 | — | — | 1 | 6.22 |
| CHEMBL488146 | — | — | 1 | 6.09 |
| CHEMBL519708 | — | — | 1 | 6.07 |
| CHEMBL519636 | — | — | 1 | 6.03 |
| CHEMBL486502 | — | — | 1 | 6.01 |
| CHEMBL482469 | — | — | 1 | 5.96 |
| CHEMBL482470 | — | — | 1 | 5.92 |
| CHEMBL486501 | — | — | 1 | 5.90 |
| CHEMBL488145 | — | — | 1 | 5.79 |
| CHEMBL443725 | — | — | 1 | 5.63 |
| CHEMBL488359 | — | — | 1 | 5.48 |
| CHEMBL341638 | — | — | 1 | 5.46 |
| CHEMBL528101 | — | — | 1 | 5.42 |
| CHEMBL216926 | — | — | 1 | 5.29 |
| CHEMBL502643 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144037 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL317364 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL485881 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL448846 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL147802 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL356292 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL484296 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL146333 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL519493 | — | IC50 | = | 604.0 | nM | 6.22 |
| CHEMBL488146 | — | IC50 | = | 814.0 | nM | 6.09 |
| CHEMBL519708 | — | IC50 | = | 854.0 | nM | 6.07 |
| CHEMBL519636 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL486502 | — | IC50 | = | 987.0 | nM | 6.01 |
| CHEMBL482469 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL482470 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL486501 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL488145 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL443725 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL488359 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL341638 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL528101 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL216926 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL502643 | — | IC50 | = | 6020.0 | nM | 5.22 |