Assay Detail
Binding
CHEMBL954908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TMPK
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.04 | 4.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL449771 | — | — | 1 | 4.04 |
| CHEMBL52609 | DOXRIBTIMINE | 2.0 | 1 | - |
| CHEMBL483919 | — | — | 1 | - |
| CHEMBL222280 | BROXURIDINE | 2.0 | 1 | - |
| CHEMBL520293 | — | — | 1 | - |
| CHEMBL189878 | — | — | 1 | - |
| CHEMBL193779 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL449771 | — | Ki | = | 92000.0 | nM | 4.04 |
| CHEMBL52609 | DOXRIBTIMINE | Ki | = | 180000.0 | nM | - |
| CHEMBL483919 | — | Ki | = | 122000.0 | nM | - |
| CHEMBL222280 | BROXURIDINE | Ki | = | 214000.0 | nM | - |
| CHEMBL520293 | — | Ki | = | 790000.0 | nM | - |
| CHEMBL189878 | — | Ki | = | 293000.0 | nM | - |
| CHEMBL193779 | — | Ki | = | 252000.0 | nM | - |