Assay Detail
Functional
CHEMBL954952
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Antagonist activity at human adrenomedullin 1 receptor expressed in HEK293 cells assessed as effect on cAMP accumulation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.56 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503773 | — | — | 1 | 8.06 |
| CHEMBL509329 | — | — | 1 | 6.88 |
| CHEMBL525571 | — | — | 1 | 6.63 |
| CHEMBL509603 | — | — | 1 | 6.42 |
| CHEMBL525039 | — | — | 1 | 6.33 |
| CHEMBL525810 | — | — | 1 | 6.26 |
| CHEMBL2372187 | — | — | 1 | 6.21 |
| CHEMBL2372194 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503773 | — | IC50 | = | 8.72 | nM | 8.06 |
| CHEMBL509329 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL525571 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL509603 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL525039 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL525810 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL2372187 | — | IC50 | = | 613.0 | nM | 6.21 |
| CHEMBL2372194 | — | IC50 | = | 2242.0 | nM | 5.65 |