Assay Detail
Functional
CHEMBL954953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human adrenomedullin 2 receptor expressed in CHO cells assessed as effect on cAMP accumulation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Adrenomedullin receptor, AM2; CALCRL/RAMP3 (CHEMBL2111191) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.60 | 7.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503773 | — | — | 1 | 7.93 |
| CHEMBL509329 | — | — | 1 | 6.97 |
| CHEMBL525571 | — | — | 1 | 6.58 |
| CHEMBL525039 | — | — | 1 | 6.50 |
| CHEMBL525810 | — | — | 1 | 6.43 |
| CHEMBL509603 | — | — | 1 | 6.38 |
| CHEMBL2372187 | — | — | 1 | 6.30 |
| CHEMBL2372194 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503773 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL509329 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL525571 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL525039 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL525810 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL509603 | — | IC50 | = | 418.0 | nM | 6.38 |
| CHEMBL2372187 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL2372194 | — | IC50 | = | 2003.0 | nM | 5.70 |