Assay Detail
Binding
CHEMBL955131
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Inhibition of histidine-tagged rat recombinant MKP3 catalytic domain expressed in Escherichia coli BL21(DE3)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein phosphatase 6 (CHEMBL5511) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.98 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50620 | — | — | 1 | 5.87 |
| CHEMBL476648 | ADOCIAQUINONE B | — | 1 | 5.82 |
| CHEMBL274056 | NAPHTHAZALIN | — | 1 | 5.16 |
| CHEMBL43612 | JUGLONE | — | 1 | 4.91 |
| CHEMBL55934 | NAPHTHOQUINONE | — | 1 | 4.70 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 4.69 |
| CHEMBL500348 | — | — | 1 | 4.37 |
| CHEMBL476649 | — | — | 1 | 4.30 |
| CHEMBL508233 | — | — | 1 | - |
| CHEMBL476655 | — | — | 1 | - |
| CHEMBL8320 | BENZOQUINONE | — | 1 | - |
| CHEMBL55659 | ANTHRAQUINONE | — | 1 | - |
| CHEMBL478485 | — | — | 1 | - |
| CHEMBL462058 | — | — | 1 | - |
| CHEMBL505950 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50620 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL476648 | ADOCIAQUINONE B | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL274056 | NAPHTHAZALIN | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL43612 | JUGLONE | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL55934 | NAPHTHOQUINONE | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL590 | MENADIONE | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL500348 | — | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL476649 | — | IC50 | = | 49900.0 | nM | 4.30 |
| CHEMBL508233 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL476655 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL8320 | BENZOQUINONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL55659 | ANTHRAQUINONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL478485 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL462058 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL505950 | — | IC50 | > | 50000.0 | nM | - |