Assay Detail
Functional
CHEMBL955148
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.02 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476633 | — | — | 1 | 7.64 |
| CHEMBL477442 | — | — | 1 | 7.43 |
| CHEMBL476634 | — | — | 1 | 7.19 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.64 |
| CHEMBL516260 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476633 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL477442 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL476634 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL516260 | — | IC50 | = | 610.0 | nM | 6.21 |