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Assay Detail

CHEMBL955217

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Functional
Antileishmanial activity against Leishmania braziliensis MHOM/BR/75/M2904 promastigotes after 72 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania braziliensis
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania braziliensis (CHEMBL612878)
Type ORGANISM
Organism Leishmania braziliensis

Publication

Synthesis, biological evaluation and SAR of sulfonamide 4-methoxychalcone derivatives with potential antileishmanial activity.
Andrighetti-Fröhner CR, de Oliveira KN, Gaspar-Silva D, Pacheco LK, Joussef AC, Steindel M, Simões CM, de Souza AM, Magalhaes UO, Afonso IF, Rodrigues CR, Nunes RJ, Castro HC.
Eur J Med Chem (2009) 44 : 755 -763
PubMed 18554753 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.14 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.52
CHEMBL476397 1 5.46
CHEMBL514071 1 5.34
CHEMBL478279 1 5.25
CHEMBL478261 1 5.23
CHEMBL476162 1 5.12
CHEMBL477232 1 5.09
CHEMBL476252 1 5.07
CHEMBL478260 1 4.89
CHEMBL105496 4-METHOXY CHALCONE 1 4.78
CHEMBL935 1 4.71
CHEMBL478262 1 4.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267345 AMPHOTERICIN B IC50 = 300.0 nM 6.52
CHEMBL476397 IC50 = 3500.0 nM 5.46
CHEMBL514071 IC50 = 4600.0 nM 5.34
CHEMBL478279 IC50 = 5600.0 nM 5.25
CHEMBL478261 IC50 = 5900.0 nM 5.23
CHEMBL476162 IC50 = 7500.0 nM 5.12
CHEMBL477232 IC50 = 8100.0 nM 5.09
CHEMBL476252 IC50 = 8600.0 nM 5.07
CHEMBL478260 IC50 = 13000.0 nM 4.89
CHEMBL105496 4-METHOXY CHALCONE IC50 = 16600.0 nM 4.78
CHEMBL935 IC50 = 19600.0 nM 4.71
CHEMBL478262 IC50 = 69000.0 nM 4.16