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Assay Detail

CHEMBL955751

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CP-55940 from cannabinoid CB2 receptor in mouse spleen membrane
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Tissue Spleen
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cannabinoid receptor 2 (CHEMBL5373)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Development of novel tail-modified anandamide analogs.
Yao F, Li C, Vadivel SK, Bowman AL, Makriyannis A.
Bioorg Med Chem Lett (2008) 18 : 5912 -5915
PubMed 18723350 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 6.05 6.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL460306 1 6.62
CHEMBL473515 1 6.60
CHEMBL462608 1 6.47
CHEMBL516986 1 6.27
CHEMBL460485 1 6.22
CHEMBL516663 1 6.12
CHEMBL462607 1 6.08
CHEMBL474532 1 6.08
CHEMBL120526 METHANANDAMIDE 1 6.06
CHEMBL462572 1 6.06
CHEMBL462593 1 6.01
CHEMBL462219 1 5.99
CHEMBL460486 1 5.98
CHEMBL460307 1 5.95
CHEMBL460487 1 5.81
CHEMBL474531 1 5.69
CHEMBL462573 1 5.49
CHEMBL516628 1 5.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL460306 Ki = 240.6 nM 6.62
CHEMBL473515 Ki = 250.4 nM 6.60
CHEMBL462608 Ki = 335.0 nM 6.47
CHEMBL516986 Ki = 533.7 nM 6.27
CHEMBL460485 Ki = 605.1 nM 6.22
CHEMBL516663 Ki = 749.8 nM 6.12
CHEMBL462607 Ki = 826.3 nM 6.08
CHEMBL474532 Ki = 839.7 nM 6.08
CHEMBL120526 METHANANDAMIDE Ki = 868.0 nM 6.06
CHEMBL462572 Ki = 869.0 nM 6.06
CHEMBL462593 Ki = 987.3 nM 6.01
CHEMBL462219 Ki = 1027.0 nM 5.99
CHEMBL460486 Ki = 1054.0 nM 5.98
CHEMBL460307 Ki = 1117.0 nM 5.95
CHEMBL460487 Ki = 1564.0 nM 5.81
CHEMBL474531 Ki = 2040.0 nM 5.69
CHEMBL462573 Ki = 3255.0 nM 5.49
CHEMBL516628 Ki = 3996.0 nM 5.40