Assay Detail
Binding
CHEMBL955774
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Inhibition of human MK2
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-activated protein kinase 2 (CHEMBL2208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.42 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516802 | — | — | 1 | 7.38 |
| CHEMBL461139 | — | — | 1 | 7.29 |
| CHEMBL461140 | — | — | 1 | 7.09 |
| CHEMBL461316 | — | — | 1 | 6.82 |
| CHEMBL507348 | — | — | 1 | 6.77 |
| CHEMBL455156 | — | — | 1 | 6.72 |
| CHEMBL516504 | — | — | 1 | 6.70 |
| CHEMBL518824 | — | — | 1 | 6.54 |
| CHEMBL460091 | — | — | 1 | 6.47 |
| CHEMBL504267 | — | — | 1 | 6.46 |
| CHEMBL455396 | — | — | 1 | 6.26 |
| CHEMBL462579 | — | — | 1 | 5.91 |
| CHEMBL462372 | — | — | 1 | 5.90 |
| CHEMBL462578 | — | — | 1 | 5.89 |
| CHEMBL452086 | — | — | 1 | 5.84 |
| CHEMBL462371 | — | — | 1 | 5.77 |
| CHEMBL452085 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516802 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL461139 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL461140 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL461316 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL507348 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL455156 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL516504 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL518824 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL460091 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL504267 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL455396 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL462579 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL462372 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL462578 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL452086 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL462371 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL452085 | — | IC50 | = | 5200.0 | nM | 5.28 |