Assay Detail
Binding
CHEMBL955809
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Inhibition of p38 by TR-FRET assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.32 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496494 | — | — | 1 | 7.55 |
| CHEMBL493986 | — | — | 1 | 6.70 |
| CHEMBL487431 | — | — | 1 | 6.00 |
| CHEMBL497343 | — | — | 1 | 5.42 |
| CHEMBL498557 | — | — | 1 | 5.41 |
| CHEMBL497958 | — | — | 1 | 5.35 |
| CHEMBL522905 | — | — | 1 | 5.31 |
| CHEMBL494821 | — | — | 1 | 5.24 |
| CHEMBL504805 | — | — | 1 | 5.21 |
| CHEMBL506033 | — | — | 1 | 5.19 |
| CHEMBL496713 | — | — | 1 | 5.12 |
| CHEMBL496916 | — | — | 1 | 5.10 |
| CHEMBL497754 | — | — | 1 | 5.04 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.85 |
| CHEMBL496505 | — | — | 1 | 4.75 |
| CHEMBL525744 | — | — | 1 | 4.68 |
| CHEMBL497957 | — | — | 1 | 4.40 |
| CHEMBL525893 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496494 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL493986 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL487431 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL497343 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL498557 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL497958 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL522905 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL494821 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL504805 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL506033 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL496713 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL496916 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL497754 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL941 | IMATINIB | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL496505 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL525744 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL497957 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL525893 | — | IC50 | = | 40000.0 | nM | 4.40 |