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Assay Detail

CHEMBL956072

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of dog F10a
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canis lupus familiaris
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action.
Van Huis CA, Casimiro-Garcia A, Bigge CF, Cody WL, Dudley DA, Filipski KJ, Heemstra RJ, Kohrt JT, Leadley RJ, Narasimhan LS, McClanahan T, Mochalkin I, Pamment M, Peterson JT, Sahasrabudhe V, Schaum RP, Edmunds JJ.
Bioorg Med Chem (2009) 17 : 2501 -2511
PubMed 19231206 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 9.05 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL474678 1 9.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL474678 IC50 = 0.887 nM 9.05