Assay Detail
Binding
CHEMBL956508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]rosigliatzone from PPARgamma in rat adipocytes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL4797) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New PPARgamma ligands based on 2-hydroxy-1,4-naphthoquinone: computer-aided design, synthesis, and receptor-binding studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.65 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482525 | — | — | 1 | 6.70 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.16 |
| CHEMBL519968 | — | — | 1 | 5.72 |
| CHEMBL482524 | — | — | 1 | 5.44 |
| CHEMBL482531 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482525 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL595 | PIOGLITAZONE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL519968 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL482524 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL482531 | — | IC50 | = | 56200.0 | nM | 4.25 |