Assay Detail
Functional
CHEMBL956587
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Inhibition of LPS-stimulated TNFalpha release from human PBMC after 3 hrs
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.28 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL461140 | — | — | 1 | 7.40 |
| CHEMBL461139 | — | — | 1 | 6.96 |
| CHEMBL516802 | — | — | 1 | 6.82 |
| CHEMBL516504 | — | — | 1 | 6.46 |
| CHEMBL461316 | — | — | 1 | 6.42 |
| CHEMBL504267 | — | — | 1 | 5.96 |
| CHEMBL518824 | — | — | 1 | 5.82 |
| CHEMBL507348 | — | — | 1 | 5.64 |
| CHEMBL455156 | — | — | 1 | 5.00 |
| CHEMBL462578 | — | — | 1 | - |
| CHEMBL462371 | — | — | 1 | - |
| CHEMBL462372 | — | — | 1 | - |
| CHEMBL460091 | — | — | 1 | - |
| CHEMBL452086 | — | — | 1 | - |
| CHEMBL452085 | — | — | 1 | - |
| CHEMBL455396 | — | — | 1 | - |
| CHEMBL462579 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL461140 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL461139 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL516802 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL516504 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL461316 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL504267 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL518824 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL507348 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL455156 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL462578 | — | IC50 | - | — | - | |
| CHEMBL462371 | — | IC50 | - | — | - | |
| CHEMBL462372 | — | IC50 | - | — | - | |
| CHEMBL460091 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL452086 | — | IC50 | - | — | - | |
| CHEMBL452085 | — | IC50 | - | — | - | |
| CHEMBL455396 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL462579 | — | IC50 | - | — | - |