Assay Detail
Binding
CHEMBL956592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cells
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK93 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcitonin gene-related peptide type 1 receptor (CHEMBL3798) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent benzimidazolone-based CGRP receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.86 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453643 | — | — | 1 | 9.29 |
| CHEMBL519421 | — | — | 1 | 8.77 |
| CHEMBL487068 | — | — | 1 | 8.72 |
| CHEMBL488082 | — | — | 1 | 8.68 |
| CHEMBL455458 | — | — | 1 | 8.66 |
| CHEMBL530116 | — | — | 1 | 8.57 |
| CHEMBL488083 | — | — | 1 | 8.37 |
| CHEMBL455674 | — | — | 1 | 8.33 |
| CHEMBL471358 | — | — | 1 | 8.26 |
| CHEMBL453644 | — | — | 1 | 8.15 |
| CHEMBL487244 | — | — | 1 | 8.02 |
| CHEMBL455670 | — | — | 1 | 8.02 |
| CHEMBL508016 | — | — | 1 | 7.89 |
| CHEMBL471530 | — | — | 1 | 7.89 |
| CHEMBL520905 | — | — | 1 | 7.82 |
| CHEMBL471706 | — | — | 1 | 7.82 |
| CHEMBL487076 | — | — | 1 | 7.75 |
| CHEMBL223156 | — | — | 1 | 7.68 |
| CHEMBL488255 | — | — | 1 | 7.68 |
| CHEMBL507339 | — | — | 1 | 7.66 |
| CHEMBL487077 | — | — | 1 | 7.64 |
| CHEMBL471704 | — | — | 1 | 7.58 |
| CHEMBL487240 | — | — | 1 | 7.58 |
| CHEMBL509718 | — | — | 1 | 7.51 |
| CHEMBL470321 | — | — | 1 | 7.50 |
| CHEMBL453865 | — | — | 1 | 7.44 |
| CHEMBL521076 | — | — | 1 | 7.43 |
| CHEMBL221009 | — | — | 1 | 7.42 |
| CHEMBL471359 | — | — | 1 | 7.39 |
| CHEMBL519242 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453643 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL519421 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL487068 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL488082 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL455458 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL530116 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL488083 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL455674 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL471358 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL453644 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL487244 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL455670 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL508016 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL471530 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL471706 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL520905 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL487076 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL223156 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL488255 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL507339 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL487077 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL471704 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL487240 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL509718 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL470321 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL453865 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL521076 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL221009 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL471359 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL519242 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL471705 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL488065 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL488066 | — | Ki | = | 250.0 | nM | 6.60 |