Assay Detail
Binding
CHEMBL956628
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Activation of ATP-sensitive potassium channel in Wistar rat pancreatic beta islets assessed as inhibition of glucose-induced insulin secretion
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.74 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302269 | — | — | 1 | 4.85 |
| CHEMBL520811 | — | — | 1 | 4.72 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.71 |
| CHEMBL508589 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302269 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL520811 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL508589 | — | IC50 | = | 22000.0 | nM | 4.66 |