Assay Detail
Binding
CHEMBL956659
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at monkey GnRH receptor
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca mulatta |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gonadotropin-releasing hormone receptor (CHEMBL5647) ↗| Type | SINGLE PROTEIN |
| Organism | Macaca mulatta |
Publication
Non-peptide gonadotropin-releasing hormone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.81 | 9.22 |
| Ki | 2 | 8.88 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120432 | — | — | 1 | 9.30 |
| CHEMBL22055 | SUFUGOLIX | 2.0 | 1 | 9.22 |
| CHEMBL179691 | — | — | 1 | 8.46 |
| CHEMBL71917 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120432 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL22055 | SUFUGOLIX | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL179691 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL71917 | — | IC50 | = | 4.0 | nM | 8.40 |