Assay Detail
Binding
CHEMBL956664
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Binding affinity at human GnRH receptor by competition binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Non-peptide gonadotropin-releasing hormone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.84 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460480 | — | — | 1 | 8.80 |
| CHEMBL494797 | — | — | 1 | 8.28 |
| CHEMBL468565 | — | — | 1 | 8.18 |
| CHEMBL512893 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460480 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL494797 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL468565 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL512893 | — | IC50 | = | 800.0 | nM | 6.10 |