Assay Detail
Binding
CHEMBL956746
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Inhibition of HIV integrase strand transfer activity
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.34 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470418 | — | — | 1 | 8.30 |
| CHEMBL513189 | — | — | 1 | 7.55 |
| CHEMBL469365 | — | — | 1 | 7.41 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.40 |
| CHEMBL513363 | — | — | 1 | 7.28 |
| CHEMBL451850 | — | — | 1 | 7.21 |
| CHEMBL470417 | — | — | 1 | 7.13 |
| CHEMBL469356 | — | — | 1 | 6.92 |
| CHEMBL512324 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470418 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL513189 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL469365 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL254316 | RALTEGRAVIR | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL513363 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL451850 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL470417 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL469356 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL512324 | — | IC50 | = | 135.0 | nM | 6.87 |