Assay Detail
Functional
CHEMBL956768
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Cytotoxicity against human MCF7 cells by resazurin reduction test
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.65 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476957 | — | — | 1 | 4.82 |
| CHEMBL505539 | — | — | 1 | 4.75 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.39 |
| CHEMBL508839 | — | — | 1 | - |
| CHEMBL507580 | — | — | 1 | - |
| CHEMBL506403 | — | — | 1 | - |
| CHEMBL522595 | — | — | 1 | - |
| CHEMBL496855 | ALLOBETULIN | — | 1 | - |
| CHEMBL23236 | BETULIN | — | 1 | - |
| CHEMBL289191 | LUPEOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476957 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL505539 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL508839 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL507580 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL506403 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL522595 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL496855 | ALLOBETULIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL23236 | BETULIN | IC50 | - | — | - | |
| CHEMBL289191 | LUPEOL | IC50 | > | 50000.0 | nM | - |