Assay Detail
Functional
CHEMBL957058
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223250 | — | — | 1 | 9.00 |
| CHEMBL455284 | — | — | 1 | 9.00 |
| CHEMBL282346 | — | — | 1 | 9.00 |
| CHEMBL385064 | — | — | 1 | 8.70 |
| CHEMBL507986 | — | — | 1 | 8.70 |
| CHEMBL442071 | — | — | 1 | 8.52 |
| CHEMBL446813 | — | — | 1 | 7.96 |
| CHEMBL390195 | — | — | 1 | 6.30 |
| CHEMBL416771 | — | — | 1 | 5.45 |
| CHEMBL556 | DEFEROXAMINE | 4.0 | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223250 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL455284 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL282346 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL385064 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL507986 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL442071 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL446813 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL390195 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL416771 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL556 | DEFEROXAMINE | IC50 | = | 7350.0 | nM | 5.13 |