Assay Detail
Binding
CHEMBL957239
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Inhibition of Staphylococcus aureus DNA gyrase gyrA S84L mutant supercoiling activity assessed as effect on conversion of relaxed pBR322 DNA to supercoiled form
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.48 | 4.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220656 | — | — | 1 | 4.67 |
| CHEMBL219534 | — | — | 1 | 4.28 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | - |
| CHEMBL430 | GEMIFLOXACIN | 4.0 | 1 | - |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220656 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL219534 | — | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | > | 300000.0 | nM | - |
| CHEMBL430 | GEMIFLOXACIN | IC50 | > | 300000.0 | nM | - |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 227000.0 | nM | - |