Assay Detail
Binding
CHEMBL957241
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Inhibition of Staphylococcus aureus wild-type topoisomerase 4 grlA S80F mutant decatenation activity assessed as unlinking of DNA microcircles from kinetoplast DNA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.94 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220656 | — | — | 1 | 5.03 |
| CHEMBL430 | GEMIFLOXACIN | 4.0 | 1 | 5.01 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 4.92 |
| CHEMBL219534 | — | — | 1 | 4.80 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220656 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL430 | GEMIFLOXACIN | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL219534 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | > | 40000.0 | nM | - |