Assay Detail
Binding
CHEMBL957255
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Inhibition of calf brain tubulin polymerization after 20 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.31 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504238 | — | — | 1 | 5.75 |
| CHEMBL276625 | PHENSTATIN | — | 1 | 5.60 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.52 |
| CHEMBL230846 | — | — | 1 | 5.24 |
| CHEMBL488141 | — | — | 1 | 5.23 |
| CHEMBL230741 | — | — | 1 | 5.10 |
| CHEMBL237475 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504238 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL276625 | PHENSTATIN | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL230846 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL488141 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL230741 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL237475 | — | IC50 | = | 18000.0 | nM | 4.75 |