Assay Detail
Functional
CHEMBL957256
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Cytotoxicity against human HeLa cells after 72 hrs by XTT method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.37 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL519245 | — | — | 1 | 8.19 |
| CHEMBL230846 | — | — | 1 | 7.80 |
| CHEMBL276625 | PHENSTATIN | — | 1 | 7.52 |
| CHEMBL230741 | — | — | 1 | 7.47 |
| CHEMBL504238 | — | — | 1 | 6.44 |
| CHEMBL520145 | — | — | 1 | 5.64 |
| CHEMBL483333 | — | — | 1 | - |
| CHEMBL483330 | — | — | 1 | - |
| CHEMBL519649 | — | — | 1 | - |
| CHEMBL483534 | — | — | 1 | - |
| CHEMBL482670 | — | — | 1 | - |
| CHEMBL482471 | — | — | 1 | - |
| CHEMBL519396 | — | — | 1 | - |
| CHEMBL487314 | — | — | 1 | - |
| CHEMBL237475 | — | — | 1 | - |
| CHEMBL488141 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL519245 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL230846 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL276625 | PHENSTATIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL230741 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL504238 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL520145 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL483333 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL483330 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL519649 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL483534 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL482670 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL482471 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL519396 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL487314 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL237475 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL488141 | — | IC50 | > | 1000.0 | nM | - |