Assay Detail
Binding
CHEMBL957261
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Inhibition of rat brain recombinant nNOS
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.96 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479014 | — | — | 1 | 5.75 |
| CHEMBL451541 | — | — | 1 | 5.60 |
| CHEMBL484298 | — | — | 1 | 4.60 |
| CHEMBL247378 | 7-NITROINDAZOLE | — | 1 | 4.60 |
| CHEMBL451401 | — | — | 1 | 4.26 |
| CHEMBL354723 | — | — | 1 | - |
| CHEMBL456579 | — | — | 1 | - |
| CHEMBL510569 | — | — | 1 | - |
| CHEMBL463676 | — | — | 1 | - |
| CHEMBL278175 | — | — | 1 | - |
| CHEMBL473471 | — | — | 1 | - |
| CHEMBL516741 | — | — | 1 | - |
| CHEMBL510692 | — | — | 1 | - |
| CHEMBL516740 | — | — | 1 | - |
| CHEMBL452956 | — | — | 1 | - |
| CHEMBL499583 | — | — | 1 | - |
| CHEMBL504883 | — | — | 1 | - |
| CHEMBL484297 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479014 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL451541 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL484298 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL247378 | 7-NITROINDAZOLE | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL451401 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL354723 | — | IC50 | = | 700000.0 | nM | - |
| CHEMBL456579 | — | IC50 | = | 750000.0 | nM | - |
| CHEMBL510569 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL463676 | — | IC50 | = | 850000.0 | nM | - |
| CHEMBL278175 | — | IC50 | = | 700000.0 | nM | - |
| CHEMBL473471 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL516741 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL510692 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL516740 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL452956 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL499583 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL504883 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL484297 | — | IC50 | = | 500000000.0 | nM | - |