Assay Detail
Functional
CHEMBL957282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human KB cells after 72 hrs
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New C5-alkylated indolobenzazepinones acting as inhibitors of tubulin polymerization: cytotoxic and antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.50 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.70 |
| CHEMBL487315 | — | — | 1 | 7.50 |
| CHEMBL502568 | — | — | 1 | 7.46 |
| CHEMBL485882 | — | — | 1 | 7.46 |
| CHEMBL529447 | — | — | 1 | 7.43 |
| CHEMBL486504 | N-ACETYLCOLCHINOL | -1.0 | 1 | 7.12 |
| CHEMBL526705 | — | — | 1 | 7.10 |
| CHEMBL486085 | — | — | 1 | 6.55 |
| CHEMBL486906 | — | — | 1 | 6.55 |
| CHEMBL520878 | — | — | 1 | 6.47 |
| CHEMBL521195 | — | — | 1 | 6.44 |
| CHEMBL486086 | — | — | 1 | 6.30 |
| CHEMBL525978 | — | — | 1 | 6.26 |
| CHEMBL521033 | — | — | 1 | 5.46 |
| CHEMBL520863 | — | — | 1 | 5.16 |
| CHEMBL488353 | — | — | 1 | 4.92 |
| CHEMBL486300 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL487315 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL502568 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL485882 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL529447 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL486504 | N-ACETYLCOLCHINOL | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL526705 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL486085 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL486906 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL520878 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL521195 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL486086 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL525978 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL521033 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL520863 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL488353 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL486300 | — | IC50 | = | 28000.0 | nM | 4.55 |