Assay Detail
Binding
CHEMBL957283
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Inhibition of sheep brain tubulin polymerization
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New C5-alkylated indolobenzazepinones acting as inhibitors of tubulin polymerization: cytotoxic and antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.56 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485882 | — | — | 1 | 6.00 |
| CHEMBL486085 | — | — | 1 | 5.77 |
| CHEMBL502568 | — | — | 1 | 5.75 |
| CHEMBL526705 | — | — | 1 | 5.72 |
| CHEMBL529447 | — | — | 1 | 5.72 |
| CHEMBL487315 | — | — | 1 | 5.70 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.66 |
| CHEMBL486504 | N-ACETYLCOLCHINOL | -1.0 | 1 | 5.52 |
| CHEMBL486086 | — | — | 1 | 5.44 |
| CHEMBL521033 | — | — | 1 | 4.29 |
| CHEMBL525978 | — | — | 1 | - |
| CHEMBL520863 | — | — | 1 | - |
| CHEMBL486300 | — | — | 1 | - |
| CHEMBL488353 | — | — | 1 | - |
| CHEMBL521195 | — | — | 1 | - |
| CHEMBL520878 | — | — | 1 | - |
| CHEMBL486906 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485882 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL486085 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL502568 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL526705 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL529447 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL487315 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL107 | COLCHICINE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL486504 | N-ACETYLCOLCHINOL | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL486086 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL521033 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL525978 | — | IC50 | - | — | - | |
| CHEMBL520863 | — | IC50 | - | — | - | |
| CHEMBL486300 | — | IC50 | - | — | - | |
| CHEMBL488353 | — | IC50 | - | — | - | |
| CHEMBL521195 | — | IC50 | - | — | - | |
| CHEMBL520878 | — | IC50 | - | — | - | |
| CHEMBL486906 | — | IC50 | - | — | - |