Assay Detail
Functional
CHEMBL957286
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 by [3H]hypoxanthine uptake
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.75 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485881 | — | — | 1 | 7.82 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.80 |
| CHEMBL144037 | — | — | 1 | 7.75 |
| CHEMBL317364 | — | — | 1 | 7.68 |
| CHEMBL448846 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485881 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL144037 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL317364 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL448846 | — | IC50 | = | 21.0 | nM | 7.68 |