Assay Detail
Functional
CHEMBL957293
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Inhibition of haemozoin formation at pH 5.2 after 18 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.54 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356292 | — | — | 1 | 4.62 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.46 |
| CHEMBL484296 | — | — | 1 | - |
| CHEMBL341638 | — | — | 1 | - |
| CHEMBL482469 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356292 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL484296 | — | IC50 | = | 199000.0 | nM | - |
| CHEMBL341638 | — | IC50 | = | 216000.0 | nM | - |
| CHEMBL482469 | — | IC50 | > | 1000000.0 | nM | - |