Assay Detail
Binding
CHEMBL957338
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Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO cells
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.19 | 8.25 |
| pKi | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489493 | — | — | 1 | 8.25 |
| CHEMBL493014 | — | — | 1 | 8.25 |
| CHEMBL494982 | — | — | 1 | 8.08 |
| CHEMBL449840 | — | — | 1 | - |
| CHEMBL451399 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489493 | — | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL493014 | — | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL494982 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL449840 | — | pKi | - | — | - | |
| CHEMBL451399 | — | pKi | - | — | - |