Assay Detail
Functional
CHEMBL957394
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay
27
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.18 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523939 | — | — | 1 | 9.00 |
| CHEMBL489474 | — | — | 1 | 9.00 |
| CHEMBL489463 | — | — | 1 | 9.00 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.70 |
| CHEMBL523801 | — | — | 1 | 8.70 |
| CHEMBL530333 | — | — | 1 | 8.70 |
| CHEMBL488457 | — | — | 1 | 8.70 |
| CHEMBL524102 | — | — | 1 | 8.70 |
| CHEMBL523263 | — | — | 1 | 7.70 |
| CHEMBL489268 | — | — | 1 | 7.30 |
| CHEMBL453902 | — | — | 1 | 7.30 |
| CHEMBL453903 | — | — | 1 | 6.82 |
| CHEMBL515133 | — | — | 3 | 6.75 |
| CHEMBL454888 | — | — | 1 | 6.70 |
| CHEMBL455692 | — | — | 1 | 6.66 |
| CHEMBL488458 | — | — | 1 | 6.60 |
| CHEMBL510689 | — | — | 1 | 6.60 |
| CHEMBL455132 | — | — | 1 | 6.26 |
| CHEMBL507815 | — | — | 1 | 6.19 |
| CHEMBL489269 | — | — | 1 | 6.12 |
| CHEMBL454889 | — | — | 1 | 6.00 |
| CHEMBL524101 | — | — | 3 | 5.80 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489474 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL523939 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL489463 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL524102 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL488457 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL530333 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL523801 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL523263 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL453902 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL489268 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL453903 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL515133 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL515133 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL515133 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL454888 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL455692 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL488458 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL510689 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL455132 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL507815 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL489269 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL454889 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL524101 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL524101 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL524101 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2500.0 | nM | 5.60 |