Assay Detail
Functional
CHEMBL957398
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Antiproliferative activity against human HeLa cells after 96 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.30 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL530333 | — | — | 1 | 9.00 |
| CHEMBL489474 | — | — | 1 | 8.70 |
| CHEMBL488457 | — | — | 1 | 8.70 |
| CHEMBL524102 | — | — | 1 | 8.52 |
| CHEMBL489463 | — | — | 1 | 8.30 |
| CHEMBL523939 | — | — | 1 | 8.30 |
| CHEMBL523263 | — | — | 1 | 8.00 |
| CHEMBL523801 | — | — | 1 | 8.00 |
| CHEMBL489268 | — | — | 1 | 7.30 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.16 |
| CHEMBL453902 | — | — | 1 | 7.05 |
| CHEMBL488458 | — | — | 1 | 7.00 |
| CHEMBL453903 | — | — | 1 | 7.00 |
| CHEMBL515133 | — | — | 1 | 6.82 |
| CHEMBL507815 | — | — | 1 | 6.82 |
| CHEMBL455692 | — | — | 1 | 6.82 |
| CHEMBL510689 | — | — | 1 | 6.70 |
| CHEMBL489269 | — | — | 1 | 6.70 |
| CHEMBL454888 | — | — | 1 | 6.68 |
| CHEMBL455132 | — | — | 1 | 6.68 |
| CHEMBL454889 | — | — | 1 | 6.21 |
| CHEMBL524101 | — | — | 1 | 6.01 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL530333 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL489474 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL488457 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL524102 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL489463 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL523939 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL523263 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL523801 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL489268 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL453902 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL488458 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL453903 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL515133 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL507815 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL455692 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL510689 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL489269 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL454888 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL455132 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL454889 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL524101 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3000.0 | nM | 5.52 |