Assay Detail
ADMET
CHEMBL957402
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Antiproliferative activity against human MRC5 cells after 96 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.02 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.52 |
| CHEMBL488457 | — | — | 1 | 6.10 |
| CHEMBL489463 | — | — | 1 | 6.07 |
| CHEMBL523263 | — | — | 1 | 6.00 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL488457 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL489463 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL523263 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3900.0 | nM | 5.41 |