Assay Detail
Binding
CHEMBL957463
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Inhibition of VEGFR2 expressed in human tumor cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.88 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL474538 | — | — | 1 | 5.29 |
| CHEMBL499345 | — | — | 1 | 5.25 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 4.97 |
| CHEMBL484109 | — | — | 1 | 4.78 |
| CHEMBL499067 | — | — | 1 | 4.60 |
| CHEMBL482489 | — | — | 1 | 4.37 |
| CHEMBL499344 | — | — | 1 | - |
| CHEMBL485320 | — | — | 1 | - |
| CHEMBL519147 | — | — | 1 | - |
| CHEMBL502015 | — | — | 1 | - |
| CHEMBL482715 | — | — | 1 | - |
| CHEMBL484108 | — | — | 1 | - |
| CHEMBL485321 | — | — | 1 | - |
| CHEMBL483313 | — | — | 1 | - |
| CHEMBL520803 | — | — | 1 | - |
| CHEMBL483108 | — | — | 1 | - |
| CHEMBL504416 | — | — | 1 | - |
| CHEMBL483312 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL474538 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL499345 | — | IC50 | = | 5580.0 | nM | 5.25 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL484109 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL499067 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL482489 | — | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL499344 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL485320 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL519147 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL502015 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL482715 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL484108 | — | IC50 | - | — | - | |
| CHEMBL485321 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL483313 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL520803 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL483108 | — | IC50 | = | 198300.0 | nM | - |
| CHEMBL504416 | — | IC50 | = | 132100.0 | nM | - |
| CHEMBL483312 | — | IC50 | > | 200000.0 | nM | - |