Assay Detail
Binding
CHEMBL957513
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Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.72 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480419 | — | — | 1 | 7.85 |
| CHEMBL469987 | — | — | 1 | 7.82 |
| CHEMBL470193 | — | — | 1 | 7.28 |
| CHEMBL512136 | — | — | 1 | 6.40 |
| CHEMBL513702 | — | — | 1 | 5.64 |
| CHEMBL469366 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480419 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL469987 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL470193 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL512136 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL513702 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL469366 | — | Ki | = | 5000.0 | nM | 5.30 |