Assay Detail
Binding
CHEMBL957523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant carbonic anhydrase 2-catalyzed CO2 hydration by stopped flow assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 4.68 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107217 | DITIOCARB SODIUM | 2.0 | 1 | 5.51 |
| CHEMBL471245 | SODIUM CARBONOTRITHIOATE | — | 1 | 5.06 |
| CHEMBL502764 | SODIUM PERSULFATE | — | 1 | 4.08 |
| CHEMBL448089 | SODIUM SELENOCYANATE | — | 1 | 4.07 |
| CHEMBL445433 | SODIUM STANNATE | — | 1 | - |
| CHEMBL114503 | SODIUM SELENATE | 3.0 | 1 | - |
| CHEMBL471869 | SODIUM TELLURATE | — | 1 | - |
| CHEMBL1076628 | SODIUM DIOXIDOTRIOXOOSMIUM | — | 1 | - |
| CHEMBL111016 | SODIUM PYROSULFATE | — | 1 | - |
| CHEMBL450079 | SODIUM PYROPHOSPHATE | -1.0 | 1 | - |
| CHEMBL1075630 | SODIUM DIVANADATE | — | 1 | - |
| CHEMBL444819 | SODIUM PERRHENATE | — | 1 | - |
| CHEMBL471244 | SODIUM IMINODISULFONATE | — | 1 | - |
| CHEMBL450253 | SODIUM FLUOROSULFATE | — | 1 | - |
| CHEMBL1081267 | SODIUM PERRUTHENATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107217 | DITIOCARB SODIUM | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL471245 | SODIUM CARBONOTRITHIOATE | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL502764 | SODIUM PERSULFATE | Ki | = | 84000.0 | nM | 4.08 |
| CHEMBL448089 | SODIUM SELENOCYANATE | Ki | = | 86000.0 | nM | 4.07 |
| CHEMBL445433 | SODIUM STANNATE | Ki | = | 830000.0 | nM | - |
| CHEMBL114503 | SODIUM SELENATE | Ki | = | 112000000.0 | nM | - |
| CHEMBL471869 | SODIUM TELLURATE | Ki | = | 920000.0 | nM | - |
| CHEMBL1076628 | SODIUM DIOXIDOTRIOXOOSMIUM | Ki | = | 950000.0 | nM | - |
| CHEMBL111016 | SODIUM PYROSULFATE | Ki | = | 970000.0 | nM | - |
| CHEMBL450079 | SODIUM PYROPHOSPHATE | Ki | = | 48500000.0 | nM | - |
| CHEMBL1075630 | SODIUM DIVANADATE | Ki | = | 570000.0 | nM | - |
| CHEMBL444819 | SODIUM PERRHENATE | Ki | = | 750000.0 | nM | - |
| CHEMBL471244 | SODIUM IMINODISULFONATE | Ki | = | 760000.0 | nM | - |
| CHEMBL450253 | SODIUM FLUOROSULFATE | Ki | = | 460000.0 | nM | - |
| CHEMBL1081267 | SODIUM PERRUTHENATE | Ki | = | 690000.0 | nM | - |