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Assay Detail

CHEMBL957581

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of cJNK phosphorylation by pepJIP1 displacement DELFIA assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors.
De SK, Chen LH, Stebbins JL, Machleidt T, Riel-Mehan M, Dahl R, Chen V, Yuan H, Barile E, Emdadi A, Murphy R, Pellecchia M.
Bioorg Med Chem (2009) 17 : 2712 -2717
PubMed 19282190 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.47 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL475637 1 7.70
CHEMBL508112 BENZOTHIAZYL DISULFIDE 1 7.01
CHEMBL474804 1 7.00
CHEMBL494333 1 6.96
CHEMBL447280 1 6.89
CHEMBL494332 1 6.85
CHEMBL493539 1 6.80
CHEMBL474803 1 6.62
CHEMBL493945 1 6.54
CHEMBL446580 1 6.40
CHEMBL501113 1 6.17
CHEMBL493538 1 6.10
CHEMBL473441 1 6.00
CHEMBL447732 1 5.82
CHEMBL493341 1 5.82
CHEMBL445426 1 5.77
CHEMBL474454 1 5.50
CHEMBL452178 1 -
CHEMBL442827 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL475637 IC50 = 20.0 nM 7.70
CHEMBL508112 BENZOTHIAZYL DISULFIDE IC50 = 98.0 nM 7.01
CHEMBL474804 IC50 = 100.0 nM 7.00
CHEMBL494333 IC50 = 110.0 nM 6.96
CHEMBL447280 IC50 = 130.0 nM 6.89
CHEMBL494332 IC50 = 140.0 nM 6.85
CHEMBL493539 IC50 = 160.0 nM 6.80
CHEMBL474803 IC50 = 240.0 nM 6.62
CHEMBL493945 IC50 = 290.0 nM 6.54
CHEMBL446580 IC50 = 400.0 nM 6.40
CHEMBL501113 IC50 = 670.0 nM 6.17
CHEMBL493538 IC50 = 796.0 nM 6.10
CHEMBL473441 IC50 = 1000.0 nM 6.00
CHEMBL447732 IC50 = 1500.0 nM 5.82
CHEMBL493341 IC50 = 1500.0 nM 5.82
CHEMBL445426 IC50 = 1700.0 nM 5.77
CHEMBL474454 IC50 = 3200.0 nM 5.50
CHEMBL452178 IC50 > 1000.0 nM -
CHEMBL442827 IC50 > 1000.0 nM -