Assay Detail
Binding
CHEMBL957610
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Inhibition of HIV1 recombinant integrase strand transfer activity
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.47 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523678 | — | — | 1 | 8.05 |
| CHEMBL492930 | — | — | 1 | 7.75 |
| CHEMBL494944 | — | — | 1 | 7.75 |
| CHEMBL523833 | — | — | 1 | 7.75 |
| CHEMBL492538 | — | — | 1 | 7.72 |
| CHEMBL492329 | — | — | 1 | 7.68 |
| CHEMBL492543 | — | — | 1 | 7.68 |
| CHEMBL492350 | — | — | 1 | 7.68 |
| CHEMBL494945 | — | — | 1 | 7.68 |
| CHEMBL495145 | — | — | 1 | 7.68 |
| CHEMBL499184 | — | — | 1 | 7.66 |
| CHEMBL492932 | — | — | 1 | 7.64 |
| CHEMBL492526 | — | — | 1 | 7.62 |
| CHEMBL522653 | — | — | 1 | 7.60 |
| CHEMBL492537 | — | — | 1 | 7.58 |
| CHEMBL522534 | — | — | 1 | 7.44 |
| CHEMBL493335 | — | — | 1 | 7.44 |
| CHEMBL492328 | — | — | 1 | 7.30 |
| CHEMBL495144 | — | — | 1 | 7.30 |
| CHEMBL493531 | — | — | 1 | 7.16 |
| CHEMBL492727 | — | — | 1 | 6.89 |
| CHEMBL492524 | — | — | 1 | 6.77 |
| CHEMBL494946 | — | — | 1 | 6.73 |
| CHEMBL492525 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523678 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL492930 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL494944 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL523833 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL492538 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL492329 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL492543 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL492350 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL494945 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL495145 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL499184 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL492932 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL492526 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL522653 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL492537 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL522534 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL493335 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL492328 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL495144 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL493531 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL492727 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL492524 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL494946 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL492525 | — | IC50 | = | 185.0 | nM | 6.73 |