Assay Detail
Binding
CHEMBL957877
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Binding affinity to HIV1 recombinant reverse transcriptase p66/p51 K103N mutant at enzyme-DNA-dNTP tertiary complex state
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.53 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516649 | — | — | 1 | 8.82 |
| CHEMBL454929 | — | — | 1 | 7.30 |
| CHEMBL517753 | — | — | 1 | 7.30 |
| CHEMBL225004 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516649 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL454929 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL517753 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL225004 | — | Ki | = | 200.0 | nM | 6.70 |