Assay Detail
Binding
CHEMBL957971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CDK4/cyclin D1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.53 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201511 | MALEIMIDE | — | 1 | 4.85 |
| CHEMBL488646 | — | — | 1 | 4.57 |
| CHEMBL521201 | — | — | 1 | 4.52 |
| CHEMBL452812 | — | — | 1 | 4.46 |
| CHEMBL509435 | — | — | 1 | 4.40 |
| CHEMBL488811 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201511 | MALEIMIDE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL488646 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL521201 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL452812 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL509435 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL488811 | — | IC50 | = | 44000.0 | nM | 4.36 |