Assay Detail
Binding
CHEMBL957979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant FLT3
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.06 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201511 | MALEIMIDE | — | 1 | 6.57 |
| CHEMBL521201 | — | — | 1 | 5.66 |
| CHEMBL453593 | — | — | 1 | 5.52 |
| CHEMBL509435 | — | — | 1 | 5.30 |
| CHEMBL529663 | — | — | 1 | 5.21 |
| CHEMBL452812 | — | — | 1 | 5.00 |
| CHEMBL507056 | — | — | 1 | 4.85 |
| CHEMBL488646 | — | — | 1 | 4.70 |
| CHEMBL519590 | — | — | 1 | 4.60 |
| CHEMBL486437 | — | — | 1 | 4.47 |
| CHEMBL453336 | — | — | 1 | 4.44 |
| CHEMBL505253 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201511 | MALEIMIDE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL521201 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL453593 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL509435 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL529663 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL452812 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL507056 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL488646 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL519590 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL486437 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL453336 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL505253 | — | IC50 | = | 44000.0 | nM | 4.36 |