Assay Detail
Functional
CHEMBL958086
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Antiproliferative activity against human A427 cells after 96 hrs by crystal violet assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-427 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.53 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.89 |
| CHEMBL1489 | AZACITIDINE | 4.0 | 1 | 6.20 |
| CHEMBL522722 | — | — | 1 | 5.26 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | 5.02 |
| CHEMBL497335 | — | — | 1 | 4.93 |
| CHEMBL495692 | — | — | 1 | 4.88 |
| CHEMBL498148 | — | — | 1 | - |
| CHEMBL524817 | — | — | 1 | - |
| CHEMBL497126 | — | — | 1 | - |
| CHEMBL497763 | — | — | 1 | - |
| CHEMBL497334 | — | — | 1 | - |
| CHEMBL525713 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1489 | AZACITIDINE | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL522722 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL497335 | — | IC50 | = | 11840.0 | nM | 4.93 |
| CHEMBL495692 | — | IC50 | = | 13160.0 | nM | 4.88 |
| CHEMBL498148 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL524817 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL497126 | — | IC50 | - | — | - | |
| CHEMBL497763 | — | IC50 | - | — | - | |
| CHEMBL497334 | — | IC50 | - | — | - | |
| CHEMBL525713 | — | IC50 | - | — | - |