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Assay Detail

CHEMBL958092

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Binding
Displacement of [3H]WIN-35428 from dopamine transporter
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Sodium-dependent dopamine transporter (CHEMBL238)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives.
Jin C, Navarro HA, Carroll FI.
Bioorg Med Chem (2008) 16 : 5529 -5535
PubMed 18434164 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 8.49 9.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL495464 1 9.64
CHEMBL494626 1 9.49
CHEMBL494814 1 9.10
CHEMBL494807 1 9.10
CHEMBL522699 1 9.05
CHEMBL494624 1 8.85
CHEMBL496913 1 8.66
CHEMBL449047 1 8.44
CHEMBL524188 1 8.44
CHEMBL496911 1 8.10
CHEMBL451071 1 7.96
CHEMBL494786 1 7.64
CHEMBL523916 1 7.33
CHEMBL370805 COCAINE 4.0 1 7.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL495464 IC50 = 0.23 nM 9.64
CHEMBL494626 IC50 = 0.32 nM 9.49
CHEMBL494814 IC50 = 0.8 nM 9.10
CHEMBL494807 IC50 = 0.8 nM 9.10
CHEMBL522699 IC50 = 0.9 nM 9.05
CHEMBL494624 IC50 = 1.4 nM 8.85
CHEMBL496913 IC50 = 2.2 nM 8.66
CHEMBL449047 IC50 = 3.6 nM 8.44
CHEMBL524188 IC50 = 3.6 nM 8.44
CHEMBL496911 IC50 = 8.0 nM 8.10
CHEMBL451071 IC50 = 11.0 nM 7.96
CHEMBL494786 IC50 = 23.0 nM 7.64
CHEMBL523916 IC50 = 47.0 nM 7.33
CHEMBL370805 COCAINE IC50 = 89.1 nM 7.05