Assay Detail
Binding
CHEMBL958152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.98 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452864 | — | — | 1 | 5.07 |
| CHEMBL460491 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452864 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL460491 | — | IC50 | = | 13240.0 | nM | 4.88 |