Assay Detail
Binding
CHEMBL958183
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Displacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.36 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452847 | — | — | 1 | 7.70 |
| CHEMBL454890 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452847 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL454890 | — | Ki | = | 97.72 | nM | 7.01 |