Assay Detail
Binding
CHEMBL958321
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Agonist activity at LXRbeta ligand binding domain by FRET based SRC1 recruitment assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.20 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 8.10 |
| CHEMBL59030 | — | — | 1 | 7.11 |
| CHEMBL434302 | 24(S),25-EPOXYCHOLESTEROL | — | 1 | 6.54 |
| CHEMBL522370 | — | — | 1 | 6.24 |
| CHEMBL495173 | — | — | 1 | 6.20 |
| CHEMBL523211 | — | — | 1 | 6.10 |
| CHEMBL494843 | — | — | 1 | 6.06 |
| CHEMBL495020 | — | — | 1 | 6.03 |
| CHEMBL521866 | — | — | 1 | 5.82 |
| CHEMBL492798 | — | — | 1 | 5.72 |
| CHEMBL495197 | — | — | 1 | 5.63 |
| CHEMBL495196 | — | — | 1 | 5.58 |
| CHEMBL521811 | — | — | 1 | 5.46 |
| CHEMBL522668 | — | — | 1 | - |
| CHEMBL492563 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL59030 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL434302 | 24(S),25-EPOXYCHOLESTEROL | EC50 | = | 286.0 | nM | 6.54 |
| CHEMBL522370 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL495173 | — | EC50 | = | 626.0 | nM | 6.20 |
| CHEMBL523211 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL494843 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL495020 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL521866 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL492798 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL495197 | — | EC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL495196 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL521811 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL522668 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL492563 | — | EC50 | > | 100000.0 | nM | - |