Assay Detail
Functional
CHEMBL958323
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Agonist activity at human LXRbeta expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.05 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 7.12 |
| CHEMBL59030 | — | — | 1 | 6.89 |
| CHEMBL434302 | 24(S),25-EPOXYCHOLESTEROL | — | 1 | 6.40 |
| CHEMBL495173 | — | — | 1 | 6.09 |
| CHEMBL492798 | — | — | 1 | 6.02 |
| CHEMBL521866 | — | — | 1 | 5.80 |
| CHEMBL495196 | — | — | 1 | 5.57 |
| CHEMBL495197 | — | — | 1 | 5.42 |
| CHEMBL523211 | — | — | 1 | 5.12 |
| CHEMBL494843 | — | — | 1 | - |
| CHEMBL495020 | — | — | 1 | - |
| CHEMBL522370 | — | — | 1 | - |
| CHEMBL522668 | — | — | 1 | - |
| CHEMBL521811 | — | — | 1 | - |
| CHEMBL492563 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL59030 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL434302 | 24(S),25-EPOXYCHOLESTEROL | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL495173 | — | EC50 | = | 813.0 | nM | 6.09 |
| CHEMBL492798 | — | EC50 | = | 959.0 | nM | 6.02 |
| CHEMBL521866 | — | EC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL495196 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL495197 | — | EC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL523211 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL494843 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL495020 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL522370 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL522668 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL521811 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL492563 | — | EC50 | > | 30000.0 | nM | - |