Assay Detail
Binding
CHEMBL958366
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Displacement of [3H]mesulergine from 5HT2C receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.76 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL467736 | — | — | 1 | 7.18 |
| CHEMBL492916 | — | — | 1 | 6.91 |
| CHEMBL451232 | — | — | 1 | 6.69 |
| CHEMBL493130 | — | — | 1 | 6.62 |
| CHEMBL360328 | LORCASERIN | 4.0 | 1 | 6.59 |
| CHEMBL445747 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL467736 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL492916 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL451232 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL493130 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL360328 | LORCASERIN | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL445747 | — | Ki | = | 268.0 | nM | 6.57 |