Assay Detail
Binding
CHEMBL958368
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nisoxetine from NET
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.40 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492916 | — | — | 1 | 5.56 |
| CHEMBL467736 | — | — | 1 | 5.47 |
| CHEMBL493130 | — | — | 1 | 5.17 |
| CHEMBL360328 | LORCASERIN | 4.0 | 1 | - |
| CHEMBL445747 | — | — | 1 | - |
| CHEMBL451232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492916 | — | Ki | = | 2733.0 | nM | 5.56 |
| CHEMBL467736 | — | Ki | = | 3404.0 | nM | 5.47 |
| CHEMBL493130 | — | Ki | = | 6780.0 | nM | 5.17 |
| CHEMBL360328 | LORCASERIN | Ki | > | 10000.0 | nM | - |
| CHEMBL445747 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL451232 | — | Ki | > | 10000.0 | nM | - |